In this entertaining and illuminating program, CBC Radio's Quirks & Quarks teams up with the Perimeter Institute for Theoretical Physics in Waterloo and assembles a panel of 10 prominent physicists from around the world. Each panelist was asked to name the biggest question that science has, so far, been unable to answer. The arguments were made before a live audience at CBC Toronto.

Some of the big questions include:

How did the Universe begin? Dr. Sean Carroll, a senior research associate in physics at the California Institute of Technology.

What is the Universe made of? Dr. Katie Freese, a professor of physics at the University of Michigan.

Is there life elsewhere in the Universe? Dr. Gordon Southam, a professor of biology and earth sciences at the University of Western Ontario, and Canada Research Chair in Geo-microbiology.

Does time exist? Dr. Julian Barbour, an independent British physicist and popular science writer.

How can we travel to other stars in a human lifespan? Dr. Sabine Stanley, an assistant professor of physics at the University of Toronto.

How real is reality? Dr. Anton Zeilinger, a professor of physics at the University of Vienna.

Are there Earth-like planets elsewhere in the Universe? Paul Delaney, a senior lecturer in physics and astronomy at York University in Toronto.

What is empty space made of? Dr. Michael Luke, a professor of physics at the University of Toronto.